Cause Middle East respiratory syndrome




1 cause

1.1 virology
1.2 transmission

1.2.1 camels
1.2.2 between people







cause
virology


mers coronaviruses under electron microscope.


middle east respiratory syndrome caused newly identified mers coronavirus (mers-cov), species single-stranded rna belonging genus betacoronavirus distinct sars coronavirus , common-cold coronavirus. genomes phylogenetically classified 2 clades, clades , b. cases of mers of clade clusters (emc/2012 , jordan-n3/2012) while new cases genetically different in general (clade b). virus grows readily on vero cells , llc-mk2 cells.


transmission
camels

a study performed between 2010 , 2013, in incidence of mers evaluated in 310 dromedary camels, revealed high titers of neutralizing antibodies mers-cov in blood serum of these animals. further study sequenced mers-cov nasal swabs of dromedary camels in saudi arabia , found had sequences identical sequenced human isolates. individual camels found have more 1 genomic variant in nasopharynx. there report of saudi arabian man became ill 7 days after applying topical medicine noses of several sick camels , later , 1 of camels found have identical strains of mers-cov. still unclear how virus transmitted camels humans. world health organization advises avoiding contact camels , eat cooked camel meat, pasteurized camel milk, , avoid drinking camel urine. camel urine considered medicine various illnesses in middle east. saudi ministry of agriculture has advised people avoid contact camels or wear breathing masks when around them. in response people have refused listen government s advice , kiss camels in defiance of government s advice.


between people

there has been evidence of limited, not sustained spread of mers-cov person person, both in households in health care settings hospitals. transmission has occurred in circumstances of close contact severely ill persons in healthcare or household settings , there no evidence of transmission asymptomatic cases. cluster sizes have ranged 1 26 people, average of 2.7.








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